A team of scientists involuntarily discovered new contributions to baldness, while studying groundbreaking techniques that help hair grow back.
The researchers were attempting to spot on the way anti-inflammatory immune cells called Tregs functions with reference to in skin health generally.
They have shaved laboratory mice completely and have taken out Tregs from the mice’s skin so they can observe the results properly.
However, the fact the hair did not grow came down on the scientists.
It was thought earlier that stem cells stimulates hairs to regrow after they fall out, but the scientists found that Tregs are the real efficient factor behind the process.
Professor Michael Rosenblum, an immunologist and dermatologist at University of California San Francisco, said in the Journal Cell: “Our hair follicles are constantly recycling. When a hair falls out, the whole hair follicle has to grow back.
“This has been thought to be an entirely stem cell-dependent process, but it turns out Tregs are essential.
“If you knock out this one immune cell type, hair just doesn’t grow.
“It’s as if the skin stem cells and Tregs have co-evolved so that the Tregs not only guard the stem cells against inflammation but also take part in their regenerative work.
“The stem cells rely on the Tregs completely to know when it’s time to start regenerating.”
The scientist asserted that deficiency in Tregs could be behind the immune disease, alopecia areata, which contributes to hair and potentially baldness.
It helps heal skin wounds
Professor Rosenblum and her team have found out that Tregs help the immune systems of baby mice spot on the harmless skin microbes and that help heal skin wounds.
“We think of immune cells as coming into a tissue to fight infection, while stem cells are there to regenerate the tissue after it’s damaged,” he wrote in the journal Cell.
“But what we found here is that stem cells and immune cells have to work together to make regeneration possible.”